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As a toxin begins to turn the residents of Ogden Marsh, Iowa into violent psychopaths, sheriff David Dutton (Olyphant) tries to make sense of the situation while he, his wife (Mitchell), and two other unaffected townspeople band together in a fight for survival.
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In the future, Jake, a paraplegic war veteran, is brought to another planet, Pandora, which is inhabited by the Na’vi, a humanoid race with their own language and culture. Those from Earth find themselves at odds with each other and the local culture. 

When his brother is killed in battle, paraplegic Marine Jake Sully decides to take his place in a mission on the distant world of Pandora. There he learns of greedy corporate figurehead Parker Selfridge’s intentions of driving off the native humanoid “Na’vi” in order to mine for the precious material scattered throughout their rich woodland. In exchange for the spinal surgery that will fix his legs, Jake gathers intel for the cooperating military unit spearheaded by gung-ho Colonel Quaritch, while simultaneously attempting to infiltrate the Na’vi people with the use of an “avatar” identity. While Jake begins to bond with the native tribe and quickly falls in love with the beautiful alien Neytiri, the restless Colonel moves forward with his ruthless extermination tactics, forcing the soldier to take a stand – and fight back in an epic battle for the fate of Pandora.

Source: IMDB